Raguindin, Peter Francis; Itodo, Oche Adam; Eriks-Hoogland, Inge; Muka, Taulant; Brach, Mirjam; Stucki, Gerold; Stoyanov, Jivko; Glisic, Marija (2024). Does cardiometabolic risk profile differ among individuals with traumatic and non-traumatic spinal cord injury (SCI): the evidence from the multicenter SCI cohort in Switzerland (SwiSCI). Spinal cord, 62(7), pp. 387-395. Springer Nature 10.1038/s41393-024-00996-5
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STUDY DESIGN
Longitudinal study.
OBJECTIVE
To explore whether individuals with traumatic spinal cord injury (TSCI) and non-traumatic SCI (NTSCI) experience different trajectories in changes of cardiometabolic disease (CMD) factors during initial rehabilitation stay.
SETTING
Multicenter Swiss Spinal Cord Injury Cohort (SwiSCI) study.
METHODS
Individuals without history of cardiovascular diseases were included. CMD factors and Framingham risk score (FRS) were compared between TSCI and NTSCI. Linear mixed models' analysis was employed to explore the trajectory in CMD factors changes over rehabilitation period and a multivariate linear regression analysis was used at discharge from inpatient rehabilitation to explore factors associated with CMD risk profile in TSCI and NTSCI. We performed age and sex-stratified analyses.
RESULTS
We analyzed 530 individuals with SCI (64% with TSCI and 36% NTSCI). The median age was 53 years (IQR:39-64) with 67.9% (n = 363) of the study cohort being male. The median rehabilitation duration was 4.4 months (IQR 2.4-6.4). At admission to rehabilitation, FRS (9.61 vs. 5.89) and prevalence of hypertension (33.16% vs. 13.62%), diabetes (13.68% vs. 4.06%), and obesity (79.05% vs. 66.67%) were higher in NTSCI as compared to TSCI, No difference was observed in cardiometabolic syndrome between the groups (around 40% in both groups). Overall, we observed longitudinal increases in total cholesterol, HDL-C and HDL/total cholesterol ratio, and a decrease in fasting glucose over the rehabilitation period. No differences in longitudinal changes in cardiovascular risk factors were observed between TSCI and NTSCI.
CONCLUSIONS
There was no deterioration in cardiometabolic risk factors over rehabilitation period, at discharge from initial rehabilitation stay. Both TSCI and NTSCI experienced high burden of cardiometabolic syndrome components with NTSCI experiencing more disadvantageous risk profile. The effectiveness of therapeutic and lifestyle/behavioral strategies to decrease burden of cardiometabolic disease and its components in early phase should be explored in future studies.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Raguindin, Peter Francis, Itodo, Oche Adam, Muka, Taulant, Glisic, Marija |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1476-5624 |
Publisher: |
Springer Nature |
Funders: |
[222] Horizon 2020 ; [226] Swiss School of Public Health Global P3HS |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
16 May 2024 13:10 |
Last Modified: |
10 Jul 2024 17:05 |
Publisher DOI: |
10.1038/s41393-024-00996-5 |
PubMed ID: |
38750255 |
Additional Information: |
Open Access Funding by University of Bern. |
BORIS DOI: |
10.48350/196831 |
URI: |
https://boris.unibe.ch/id/eprint/196831 |
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