Brado, Luise; Matheisl, Daniel; Mildenberger, Eva; Fuchs, Hans; Klotz, Daniel; Kidszun, André (2024). European survey showed wide variations in diagnostic procedures and management strategies for metabolic bone disease of prematurity in 22 countries. Acta paediatrica, 113(8), pp. 1908-1915. Wiley 10.1111/apa.17273
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Acta_Paediatrica_-_2024_-_Brado_-_European_survey_showed_wide_variations_in_diagnostic_procedures_and_management_strategies.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (704kB) | Preview |
AIM
The aim of this study was to evaluate the clinical relevance, diagnostic procedures and treatment strategies for metabolic bone disease in preterm infants across Europe.
METHODS
An e-survey was distributed by email to 545 neonatal units in 38 European countries between July and October 2021. The protocol was based on the Checklist for Reporting Results of Internet E-Surveys.
RESULTS
In total, 76 neonatal units (14%) from 22 European countries (58%) completed the e-survey. In the 12 months prior to the survey, 29% of 76 units reported at least one symptomatic case of fracture associated with metabolic bone disease of prematurity, and 18% of 76 units reported at least one case of craniofacial deformity. Most centres followed local guidelines for diagnosis (77% of 73 units) and treatment (63% of 72 units). Alkaline phosphatase was the blood marker most used for treatment indication (81% of 72 units), and phosphate supplementation was the treatment most used (82% of 71 units).
CONCLUSION
Metabolic bone disease of prematurity remains clinically relevant. Wide variations in diagnostic procedures and management strategies were observed in European neonatal units. Evidence-based consensus guidelines appear urgently needed to reduce the number of symptomatic cases.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neonatology |
UniBE Contributor: |
Kidszun, André |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1651-2227 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 May 2024 11:05 |
Last Modified: |
12 Jul 2024 00:14 |
Publisher DOI: |
10.1111/apa.17273 |
PubMed ID: |
38752585 |
Uncontrolled Keywords: |
European survey fractures guidelines metabolic bone disease of prematurity practice variation |
BORIS DOI: |
10.48350/196872 |
URI: |
https://boris.unibe.ch/id/eprint/196872 |
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