Sandoval Ortega, Raquel Adaia; Renard, Margot; Cohen, Michael X; Nevian, Thomas (2024). Interactive effects of pain and arousal state on heart rate and cortical activity in the mouse anterior cingulate and somatosensory cortices. Neurobiology of pain, 15 Elsevier 10.1016/j.ynpai.2024.100157
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Sensory disconnection is a hallmark of sleep, yet the cortex retains some ability to process sensory information. Acute noxious stimulation during sleep increases the heart rate and the likelihood of awakening, indicating that certain mechanisms for pain sensing and processing remain active. However, processing of somatosensory information, including pain, during sleep remains underexplored. To assess somatosensation in natural sleep, we simultaneously recorded heart rate and local field potentials in the anterior cingulate (ACC) and somatosensory (S1) cortices of naïve, adult male mice, while applying noxious and non-noxious stimuli to their hind paws throughout their sleep-wake cycle. Noxious stimuli evoked stronger heart rate increases in both wake and non-rapid eye movement sleep (NREMS), and resulted in larger awakening probability in NREMS, as compared to non-noxious stimulation, suggesting differential processing of noxious and non-noxious information during sleep. Somatosensory information differentially reached S1 and ACC in sleep, eliciting complex transient and sustained responses in the delta, alpha, and gamma frequency bands as well as somatosensory evoked potentials. These dynamics depended on sleep state, the behavioral response to the stimulation and stimulation intensity (non-noxious vs. noxious). Furthermore, we found a correlation of the heart rate with the gamma band in S1 in the absence of a reaction in wake and sleep for noxious stimulation. These findings confirm that somatosensory information, including nociception, is sensed and processed during sleep even in the absence of a behavioral response.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology |
UniBE Contributor: |
Sandoval Ortega, Raquel Adaia, Renard, Margot Apolline, Nevian, Thomas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2452-073X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 May 2024 16:06 |
Last Modified: |
21 May 2024 16:15 |
Publisher DOI: |
10.1016/j.ynpai.2024.100157 |
PubMed ID: |
38764613 |
Uncontrolled Keywords: |
Anterior cingulate cortex Nociception Oscillations Pain Sensory processing Sleep Somatosensory cortex |
BORIS DOI: |
10.48350/196922 |
URI: |
https://boris.unibe.ch/id/eprint/196922 |
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