Ebrahimi, Fahim; Andereggen, Lukas; Christ, Emanuel R (2024). Morbidities and mortality among hospitalized patients with hypopituitarism: Prevalence, causes and management. Reviews in endocrine and metabolic disorders, 25(3), pp. 599-608. Springer 10.1007/s11154-024-09888-8
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Hypopituitarism is a highly heterogeneous multisystem disorder that can have a major impact on long-term morbidity and mortality, but even more so during acute medical conditions requiring hospitalization. Recent studies suggest a significant in-hospital burden with prolonged length of stay, increased rate of intensive care unit (ICU) admission, and initiation of mechanical ventilation - all of which may lead to an increased risk of in-hospital mortality. On the one hand, patients with hypopituitarism are often burdened by metabolic complications, including obesity, hypertension, dyslipidemia, and hyperglycemia, which alone, or in combination, are known to significantly alter relevant physiological mechanisms, including metabolism, innate and adaptive immune responses, coagulation, and wound healing, thereby contributing to adverse in-hospital outcomes. On the other hand, depending on the extent and the number of pituitary hormone deficiencies, early recognition of hormone deficiencies and appropriate management and replacement strategy within a well-organized multidisciplinary team are even stronger determinants of short-term outcomes during acute hospitalization in this vulnerable patient population. This review aims to provide an up-to-date summary of recent advances in pathophysiologic understanding, clinical implications, and recommendations for optimized multidisciplinary management of hospitalized patients with hypopituitarism.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Andereggen, Lukas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1573-2606 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 May 2024 14:10 |
Last Modified: |
10 Jun 2024 00:16 |
Publisher DOI: |
10.1007/s11154-024-09888-8 |
PubMed ID: |
38802643 |
Uncontrolled Keywords: |
AVP deficiency and resistance Hormone replacement therapy Hypopituitarism Metabolic syndorme Morbidity Mortality Outcomes Treatment |
BORIS DOI: |
10.48350/197163 |
URI: |
https://boris.unibe.ch/id/eprint/197163 |
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