Ahmad, Suhaib JS; Degiannis, Jason R; Borucki, Joseph; Pouwels, Sjaak; Rawaf, David Laith; Lala, Anil; Whiteley, Graham S; Head, Marion; Simpson, Angharad; Archid, Rami; Ahmed, Ahmed R; Soler, J Agustin; Wichmann, Doerte; Thangavelu, Mohanarangam; Abdulmajed, Mohamed; Elmousili, Mahmoud; Lin, Yan-Ren; Gelber, Edgar; Exadaktylos, Aristomenis K (2024). Fatality Rates After Infection With the Omicron Variant (B.1.1.529): How Deadly has it been? A Systematic Review and Meta-Analysis. Journal of acute medicine, 14(2), pp. 51-60. Ainosco Press 10.6705/j.jacme.202406_14(2).0001
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Fatality_Rates_After_Infection_With_the_Omicron_Variant__B.1.1.529__How_Deadly_has_it_been_A_Systema.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (2MB) |
BACKGROUND
Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.
METHODS
A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.
RESULTS
The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, p < 0.01).
CONCLUSION
The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center |
UniBE Contributor: |
Exadaktylos, Aristomenis |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2211-5587 |
Publisher: |
Ainosco Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Jun 2024 11:03 |
Last Modified: |
11 Jun 2024 11:12 |
Publisher DOI: |
10.6705/j.jacme.202406_14(2).0001 |
PubMed ID: |
38855048 |
Uncontrolled Keywords: |
B.1.1.529 COVID-19 ICU care Omicron SARS-CoV-2 intensive care |
BORIS DOI: |
10.48350/197727 |
URI: |
https://boris.unibe.ch/id/eprint/197727 |
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