Tan, Sean; Nelson, Adam J; Muthalaly, Rahul G; Ramkumar, Satish; Hamilton, Joshua; Nerlekar, Nitesh; Segelov, Eva; Nicholls, Stephen J (2024). Cardiovascular Risk in Cancer Patients Treated with Immune Checkpoint Inhibitors: Challenges and Future Directions. (In Press). European journal of preventive cardiology Oxford University Press 10.1093/eurjpc/zwae204
|
Text
zwae204.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (411kB) | Preview |
Cardiovascular disease is the leading cause of non-cancer related mortality and morbidity among people living with or cured from cancer. Immune checkpoint inhibitors (ICIs) are systemic anti-cancer therapies that have revolutionised the treatment of numerous cancers, even achieving durable long-term responses among patients with metastatic disease. However, the pro-inflammatory effects of ICIs have been postulated to increase the risk of atherosclerotic cardiovascular disease (ASCVD) in cancer survivorship. Standard modifiable cardiovascular risk factors can further contribute to ASCVD risk during cancer survivorship but are not routinely screened and are often untreated in patients with cancer. With the expanding use of ICIs leading to improved cancer survivorship, cardiovascular risk identification and prevention will be paramount in the care of patients with cancer. This review highlights the practical challenges associated with ASCVD prevention among the growing number of patients treated with ICIs for cancer, including balancing competing mortality risks from cancer and ASCVD, the lack of ICI-specific cardiovascular risk stratification tools, potential interactions between cardiovascular and oncological therapies, and barriers to implementation of cardiovascular screening and prevention within existing healthcare systems.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) |
UniBE Contributor: |
Segelov, Eva |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2047-4881 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Jun 2024 10:37 |
Last Modified: |
20 Jun 2024 14:07 |
Publisher DOI: |
10.1093/eurjpc/zwae204 |
PubMed ID: |
38870247 |
Uncontrolled Keywords: |
Atherosclerotic Cardiovascular Disease Cardio-Oncology Cardiovascular Disease Cardiovascular Risk Factors Coronary Artery Disease Immune Checkpoint Inhibitors |
BORIS DOI: |
10.48350/197826 |
URI: |
https://boris.unibe.ch/id/eprint/197826 |
Actions (login required)
 |
Edit item |