Andonie, Raphael R; Wimmer, Wilhelm; Schraivogel, Stephan; Mantokoudis, Georgios; Caversaccio, Marco; Weder, Stefan (2024). Electrocochleography in Cochlear Implant Recipients: Correlating Maximum Response With Residual Hearing. (In Press). Ear and hearing Lippincott Williams & Wilkins 10.1097/AUD.0000000000001546
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OBJECTIVES
Electrocochleography (ECochG) is increasingly recognized as a biomarker for assessing inner ear function in cochlear implant patients. This study aimed to objectively determine intraoperative cochlear microphonic (CM) amplitude patterns and correlate them with residual hearing in cochlear implant recipients, addressing the limitations in current ECochG analysis that often depends on subjective visual assessment and overlook the intracochlear measurement location.
DESIGN
In this prospective study, we investigated intraoperative pure-tone ECochG following complete electrode insertion in 31 patients. We used our previously published objective analysis method to determine the maximum CM amplitude and the associated electrode position for each electrode array. Using computed tomography, we identified electrode placement and determined the corresponding tonotopic frequency using Greenwood's function. Based on this, we calculated the tonotopic shift, that is, the difference between the stimulation frequency and the estimated frequency of the electrode with the maximum CM amplitude. We evaluated the association between CM amplitude, tonotopic shift, and preoperative hearing thresholds using linear regression analysis.
RESULTS
CM amplitudes showed high variance, with values ranging from -1.479 to 4.495 dBµV. We found a statistically significant negative correlation () between maximum CM amplitudes and preoperative hearing thresholds. In addition, a significant association () between the tonotopic shift and preoperative hearing thresholds was observed. Tonotopic shifts of the maximum CM amplitudes occurred predominantly toward the basal direction.
CONCLUSIONS
The combination of objective signal analysis and the consideration of intracochlear measurement locations enhances the understanding of cochlear health and overcomes the obstacles of current ECochG analysis. We could show the link between intraoperative CM amplitudes, their spatial distributions, and preoperative hearing thresholds. Consequently, our findings enable automated analysis and bear the potential to enhance specificity of ECochG, reinforcing its role as an objective biomarker for cochlear health.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Hearing Research Laboratory 10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research |
UniBE Contributor: |
Andonie, Raphael Raschid, Wimmer, Wilhelm, Schraivogel, Stephan Christopher, Mantokoudis, Georgios, Caversaccio, Marco, Weder, Stefan Andreas |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0196-0202 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Jul 2024 08:27 |
Last Modified: |
17 Jul 2024 08:37 |
Publisher DOI: |
10.1097/AUD.0000000000001546 |
PubMed ID: |
39010266 |
BORIS DOI: |
10.48350/199039 |
URI: |
https://boris.unibe.ch/id/eprint/199039 |
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