Stritt, Kevin; Fuster, Daniel G; Dhayat, Nasser A; Bonny, Olivier; Faller, Nicolas; Christe, Andreas; Taha, Anas; Ochs, Vincent; Ortlieb, Niklas; Roth, Beat (2024). Risk factors for asymptomatic kidney stone passage in adults with recurrent kidney stones. (In Press). Clinical journal of the American Society of Nephrology Lippincott, Williams & Wilkins 10.2215/CJN.0000000000000496
Full text not available from this repository. (Request a copy)BACKGROUND
Kidney stones are a common health problem and are characterized by a high risk of recurrence. A certain number of kidney stones passed asymptomatically. Data regarding the frequency of asymptomatic spontaneous stone passages are limited.
METHODS
To assess the frequency of asymptomatic spontaneous stone passage and its covariates, we conducted a post-hoc analysis of the prospective randomized NOSTONE trial. All asymptomatic spontaneous stone passages were identified by comparing the total number of kidney stones on low-dose non-contrast CT imaging at the beginning and end of the study, considering symptomatic stone passages and surgical stone removal. The statistical analysis focused on the association of independent variables and the number of asymptomatic spontaneous stone passages using linear regression analyses.
RESULTS
Of the 416 randomized patients, 383 with both baseline and end-of-study CT were included in this analysis. The median follow-up period was 35 months, the median patient age was 49 years (IQR:40 - 55), and 20% of the patients were female. A total of 442 stone events occurred in 209 out of 383 (55%) patients: 217 out of 442 (49%) were symptomatic spontaneous stone passages, 67 out of 442 (15%) were surgically removed stones, and 158 out of 442 (36%) were asymptomatic spontaneous stone passages. The median size of asymptomatic stones (2.4 mm; IQR:1.95-3.4) and the size of symptomatic stones (2.15 mm; IQR:1.68-2.79) that passed spontaneously were not significantly different (p=0.37). The number of asymptomatic spontaneous stone passages was significantly associated with a higher number of stones on CT at randomization (P=0.001). Limitations include the lack of data on stone size at the time of passage and overrepresentation of White men.
CONCLUSIONS
Asymptomatic stone passage was common in patients with recurrent calcium-containing kidney stones. The higher the number of stones at presentation, the more likely it was that a kidney stone would spontaneously pass over time without causing any symptoms.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Fuster, Daniel Guido, Christe, Andreas, Roth, Beat |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1555-905X |
Publisher: |
Lippincott, Williams & Wilkins |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Jul 2024 16:01 |
Last Modified: |
22 Jul 2024 16:01 |
Publisher DOI: |
10.2215/CJN.0000000000000496 |
PubMed ID: |
39028573 |
URI: |
https://boris.unibe.ch/id/eprint/199110 |
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