Bertholet, Jenny; Guyer, Gian; Mueller, Silvan; Loebner, Hannes A; Volken, Werner; Aebersold, Daniel M; Manser, Peter; Fix, Michael K (2024). Robust optimization and assessment of dynamic trajectory and mixed-beam arc radiotherapy: apreliminary study. Physics in medicine and biology, 69(16) IOP Publishing 10.1088/1361-6560/ad6950
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Bertholet_et_al_2024_Phys._Med._Biol._10.1088_1361-6560_ad6950.pdf - Accepted Version Available under License Creative Commons: Attribution (CC-BY). Download (4MB) | Preview |
Dynamic trajectory radiotherapy (DTRT) and dynamic mixed-beam arc therapy (DYMBARC) exploit non-coplanarity and, for DYMBARC, simultaneously optimized photon and electron beams. Margin concepts to account for set-up uncertainties during delivery are ill-defined for electron fields. We develop robust optimization for DTRT&DYMBARC and compare dosimetric plan quality and robustness for both techniques and both optimization strategies for four cases.
Approach. Cases for different treatment sites and clinical target volume (CTV) to planning target volume (PTV) margins, m, were investigated. Dynamic gantry-table-collimator photon paths were optimized to minimize PTV/organ-at-risk (OAR) overlap in beam's-eye-view and minimize potential photon multileaf collimator (MLC) travel. For DYMBARC plans, non-isocentric partial electron arcs or static fields with shortened source-to-surface distance (80 cm) were added. Direct aperture optimization (DAO) was used to simultaneously optimize MLC-based intensity modulation for both photon and electron beams yielding deliverable PTV-based DTRT&DYMBARC plans. Robust-optimized plans used the same paths/arcs/fields. DAO with stochastic programming was used for set-up uncertainties with equal weights in all translational directions and magnitude δ such that m= 0.7δ. Robust analysis considered random errors in all directions with or without an additional systematic error in the worst 3D direction for the adjacent OARs. 
Main results. Electron contribution was 7%-41% of target dose depending on the case and optimization strategy for DYMBARC. All techniques achieved similar CTV coverage in the nominal (no error) scenario. OAR sparing was overall better in the DYMBARC plans than in the DTRT plans and DYMBARC plans were generally more robust to the considered uncertainties. OAR sparing was better in the PTV-based than in robust-optimized plans for OARs abutting or overlapping with the target volume, but more affected by uncertainties. 
Significance. Better plan robustness can be achieved with robust optimization than with margins. Combining electron arcs/fields with non-coplanar photon trajectories further improves robustness and OAR sparing.
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