Markovic, Andjela; Kovacevic, Vladimir; Brakenhoff, Timo B; Veen, Duco; Klaver, Paul; Mitratza, Marianna; Downward, George S; Grobbee, Diederick E; Cronin, Maureen; Goodale, Brianna M (2024). Physiological Response to the COVID-19 Vaccine: Insights From a Prospective, Randomized, Single-Blinded, Crossover Trial. Journal of medical internet research, 26(e51120) Centre of Global eHealth Innovation 10.2196/51120
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BACKGROUND
Rapid development and implementation of vaccines constituted a crucial step in containing the COVID-19 pandemic. A comprehensive understanding of physiological responses to these vaccines is important to build trust in medicine.
OBJECTIVE
This study aims to investigate temporal dynamics before and after COVID-19 vaccination in 4 physiological parameters as well as the duration of menstrual cycle phases.
METHODS
In a prospective trial, 17,825 adults in the Netherlands wore a medical device on their wrist for up to 9 months. The device recorded their physiological signals and synchronized with a complementary smartphone app. By means of multilevel quadratic regression, we examined changes in wearable-recorded breathing rate, wrist skin temperature, heart rate, heart rate variability, and objectively assessed the duration of menstrual cycle phases in menstruating participants to assess the effects of COVID-19 vaccination.
RESULTS
The recorded physiological signals demonstrated short-term increases in breathing rate and heart rate after COVID-19 vaccination followed by a prompt rebound to baseline levels likely reflecting biological mechanisms accompanying the immune response to vaccination. No sex differences were evident in the measured physiological responses. In menstruating participants, we found a 0.8% decrease in the duration of the menstrual phase following vaccination.
CONCLUSIONS
The observed short-term changes suggest that COVID-19 vaccines are not associated with long-term biophysical issues. Taken together, our work provides valuable insights into continuous fluctuations of physiological responses to vaccination and highlights the importance of digital solutions in health care.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
RR2-10.1186/s13063-021-05241-5.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
07 Faculty of Human Sciences > Institute of Psychology 07 Faculty of Human Sciences > Institute of Psychology > Social Neuroscience and Social Psychology |
UniBE Contributor: |
Markovic-Widmer, Andjela |
ISSN: |
1439-4456 |
Publisher: |
Centre of Global eHealth Innovation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Aug 2024 15:59 |
Last Modified: |
13 Aug 2024 23:56 |
Publisher DOI: |
10.2196/51120 |
PubMed ID: |
39083770 |
Uncontrolled Keywords: |
SARS-CoV-2 biological mechanism biosignals breathing rate development digital health heart rate immune response implementation medical device menstrual cycle sex vaccination vaccine vaccine reactogenicity wearable technology wearables |
BORIS DOI: |
10.48350/199420 |
URI: |
https://boris.unibe.ch/id/eprint/199420 |
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