Minimally invasive extracorporeal circulation versus conventional cardiopulmonary bypass in patients undergoing cardiac surgery (MiECS): Rationale and design of a multicentre randomised trial.

Anastasiadis, Kyriakos; Antonitsis, Polychronis; Papazisis, Georgios; Haidich, Bettina; Liebold, Andreas; Punjabi, Prakash; Gunaydin, Serdar; El-Essawi, Aschraf; Rao, Vivek; Serrick, Cyril; Condello, Ignazio; Nasso, Giuseppe; Bozok, Sahin; Daylan, Ahmet; Argiriadou, Helena; Deliopoulos, Apostolos; Karapanagiotidis, Georgios; Ashkanani, Fatma; Moorjani, Narain; Cale, Alex; ... (2024). Minimally invasive extracorporeal circulation versus conventional cardiopulmonary bypass in patients undergoing cardiac surgery (MiECS): Rationale and design of a multicentre randomised trial. (In Press). Perfusion, 2676591241272009, p. 2676591241272009. Sage 10.1177/02676591241272009

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INTRODUCTION

The ultimate answer to the question whether minimal invasive extracorporeal circulation (MiECC) represents the optimal perfusion technique in contemporary clinical practice remains elusive. The present study is a real-world study that focuses on specific perfusion-related clinical outcomes after cardiac surgery that could potentially be favourably affected by MiECC and thereby influence the future clinical practice.

METHODS

The MiECS study is an international, multi-centre, two-arm randomized controlled trial. Patients undergoing elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or combined procedure (CABG + AVR) using extracorporeal circulation will be randomized to MiECC or contemporary conventional cardiopulmonary bypass (cCPB). Use of optimized conventional circuits as controls is acceptable. The study design includes a range of features to prevent bias and is registered at clinicaltrials.gov (NCT05487612).

RESULTS

The primary outcome is a composite of postoperative serious adverse events that could be related to perfusion technique occurring up to 30 days postoperatively. Secondary outcomes include use of blood products, ICU and hospital length of stay (30 days) as well as health-related quality of life (30 and 90 days).

CONCLUSIONS

The MiECS trial has been designed to overcome perceived limitation of previous trials of MiECC. Results of the proposed study could affect current perfusion practice towards advancement of patient care.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy > Partial clinic Insel 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
UniBE Contributor:	Erdoes, Gabor (B)
ISSN:	0267-6591
Publisher:	Sage
Language:	English
Submitter:	Pubmed Import
Date Deposited:	07 Aug 2024 15:53
Last Modified:	08 Aug 2024 00:16
Publisher DOI:	10.1177/02676591241272009
PubMed ID:	39089011
Uncontrolled Keywords:	cardiac surgery cardiopulmonary bypass extracorporeal circulation minimal invasive
URI:	https://boris.unibe.ch/id/eprint/199444