Bieri, Shania; Möller, Burkhard; Amsler, Jennifer (2024). Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? International journal of molecular sciences, 25(15) MDPI 10.3390/ijms25158212
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Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis. While most studies have focused on rheumatoid arthritis (RA) and osteoarthritis (OA), there is limited research on spondylarthritis and crystal arthropathies. The effects of inducing or inhibiting ferroptosis on the disease strongly depend on the studied cell type. In the search for new therapeutic targets, inhibiting ferroptosis in chondrocytes might have promising effects for any type of arthritis. On the other hand, ferroptosis induction may also lead to a desired decrease of synovial fibroblasts in RA. Thus, ferroptosis research must consider the cell-type-specific effects on arthritis. Further investigation is needed to clarify these complexities.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Möller, Burkhard, Amsler, Jennifer Susann |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Aug 2024 12:21 |
Last Modified: |
12 Aug 2024 12:30 |
Publisher DOI: |
10.3390/ijms25158212 |
PubMed ID: |
39125782 |
Uncontrolled Keywords: |
RA-FLS ROS chondrocytes ferroptosis iron lipid peroxidation osteoarthritis rheumatoid arthritis |
BORIS DOI: |
10.48350/199620 |
URI: |
https://boris.unibe.ch/id/eprint/199620 |
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