Rosa, Vinicius; Silikas, Nikolaos; Yu, Baiqing; Dubey, Nileshkumar; Gopu, Sriram; Zinelis, Spiros; Lima, Adriano F; Bottino, Marco C; Ferreira, Joao N; Schmalz, Hans Gottfried; Watts, David C (2024). Guidance on the assessment of biocompatibility of biomaterials: Fundamentals and testing considerations. (In Press). Dental materials Elsevier 10.1016/j.dental.2024.07.020
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BACKGROUND
Assessing the biocompatibility of materials is crucial for ensuring the safety and well-being of patients by preventing undesirable, toxic, immune, or allergic reactions, and ensuring that materials remain functional over time without triggering adverse reactions. To ensure a comprehensive assessment, planning tests that carefully consider the intended application and potential exposure scenarios for selecting relevant assays, cell types, and testing parameters is essential. Moreover, characterizing the composition and properties of biomaterials allows for a more accurate understanding of test outcomes and the identification of factors contributing to cytotoxicity. Precise reporting of methodology and results facilitates research reproducibility and understanding of the findings by the scientific community, regulatory agencies, healthcare providers, and the general public.
AIMS
This article aims to provide an overview of the key concepts associated with evaluating the biocompatibility of biomaterials while also offering practical guidance on cellular principles, testing methodologies, and biological assays that can support in the planning, execution, and reporting of biocompatibility testing.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Schmalz, Gottfried Hans |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0109-5641 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Aug 2024 09:15 |
Last Modified: |
13 Aug 2024 09:24 |
Publisher DOI: |
10.1016/j.dental.2024.07.020 |
PubMed ID: |
39129079 |
Uncontrolled Keywords: |
Bioactive materials Biocompatibility and proliferation Cell membrane damage, death and apoptosis Dental pulp and periodontium Nanoparticles Restorative and regenerative materials Tissue engineering and regeneration |
BORIS DOI: |
10.48350/199652 |
URI: |
https://boris.unibe.ch/id/eprint/199652 |
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