Long-term outcomes of catheter ablation for atrial fibrillation in octogenarians.

Kozhuharov, Nikola; Karim, Nabeela; Creta, Antonio; Leung, Lisa W M; Veasey, Rick; Osmanagic, Armin; Kefala, Anna; Pope, Mike; Vouliotis, Apostolos; Knecht, Sven; Krisai, Philipp; Jaïs, Pierre; Martin, Claire; Sticherling, Christian; Ginks, Matthew; Ullah, Waqas; Balasubramaniam, Richard; Kalla, Manish; Gallagher, Mark M; Hunter, Ross J; ... (2024). Long-term outcomes of catheter ablation for atrial fibrillation in octogenarians. (In Press). Journal of interventional cardiac electrophysiology Springer 10.1007/s10840-024-01879-8

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BACKGROUND AND AIMS

Catheter ablation is superior to pharmacological therapy in controlling atrial fibrillation (AF). There are few data on the long-term outcome of AF ablation in octogenarian patients. This analysis aims to evaluate the outcome of AF ablation in octogenarians vs. younger patients.

METHODS

In this retrospective study in 13 centres in the UK, France, and Switzerland, the long-term outcomes of 473 consecutive octogenarian patients undergoing ablation for AF were compared to 473 matched younger controls (median age 81.3 [80.0, 83.0] vs. 64.4 [56.5, 70.7] years, 54.3% vs. 35.1% females; p-value for both < 0.001). The primary endpoint was the recurrence of atrial arrhythmia after a blanking period of 90 days within 365 days of follow-up.

RESULTS

Acute ablation success as defined as isolation of all pulmonary veins was achieved in 97% of octogenarians. Octogenarians experienced more procedural complications (11.4% vs 7.0%, p = 0.018). The median follow-up time was 281 [106, 365] days vs. 354 [220, 365] days for octogenarians vs. non-octogenarians (p < 0.001). Among octogenarians, 27.7% (131 patients) experienced a recurrence of atrial arrhythmia, in contrast to 23.5% (111 patients) in the younger group (odds ratio 1.49; 95% confidence interval 1.16-1.92; p = 0.002). In a multivariable regression model including gender, previous AF ablation, vascular disease, chronic kidney disease, CHA2DS2-VASc score, left atrial dilatation, and indwelling cardiac implantable electronic device, age above 80 remained an independent predictor of recurrence of arrhythmia.

CONCLUSION

Ablation for AF is effective in octogenarians, but is associated with slightly higher procedural complication rate and recurrence of atrial arrhythmia than in younger patients.

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