Association of reduced peak left atrial strain with supraventricular arrhythmia in adults with congenital heart disease.

Nussbaumer, Clément; Schwerzmann, Markus; Elchinova, Elena; Goulouti, Eleni; Tobler, Daniel; Greutmann, Matthias; Wustmann, Kerstin; Papa, Andrea; Schwitz, Fabienne (2024). Association of reduced peak left atrial strain with supraventricular arrhythmia in adults with congenital heart disease. (In Press). The international journal of cardiovascular imaging Springer 10.1007/s10554-024-03205-9

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Atrial arrhythmias are an important cause of morbidity and mortality in adults with congenital heart disease (ACHD). In acquired heart disease, the left atrial (LA) strain has been shown to predict supraventricular tachyarrhythmias (SVT). This study aimed to investigate whether reduced LA strain is associated with SVT in ACHD patients. This retrospective, single-center cohort study collected baseline clinical and echocardiographic data of 206 ACHD patients (157 left heart defect, 49 right heart defect). Patients with sinus rhythm at baseline and a 5-year follow-up (median age 29, IQR 22-41 years) were included. Diagnosis of sustained SVT was determined from clinical reports during the follow-up period. New or recurrent sustained SVT occurred in 16 patients (7.8%, median follow-up of 6.2 years). Patients who developed SVT were older, more likely to have diastolic dysfunction, and had larger LA dimensions, left ventricular mass, and a lower peak LA longitudinal strain (PALS). Lower PALS was associated with higher risk of SVT in patients with left and right heart defects. Patients in the lowest quartile for PALS had a 15.9-fold higher hazard ratio of SVT (95% confidence interval, 4.5 to 56.0, p < 0.001) in comparison with the top three quartiles. PALS provides information about the occurrence of SVT in the ACHD population. Including measurement of LA strain in the follow-up of these patients may allow to better identify patients at risk of future atrial arrhythmias.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Nussbaumer, Clément Enrico, Schwerzmann, Markus, Elchinova, Elena Georgieva, Wustmann, Kerstin Brigitte, Schwitz, Fabienne Muriel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1875-8312

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

16 Aug 2024 09:22

Last Modified:

16 Aug 2024 09:30

Publisher DOI:

10.1007/s10554-024-03205-9

PubMed ID:

39147918

Uncontrolled Keywords:

Adult with congenital heart disease Atrial arrhythmia Left atrial strain Speckle tracking echocardiography

BORIS DOI:

10.48350/199756

URI:

https://boris.unibe.ch/id/eprint/199756

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