Lenouvel, Eric; Tobias, Sebastian; Mühlbauer, Viktoria; Dallmeier, Dhayana; Denkinger, Michael; Klöppel, Stefan; Schönfeldt-Lecuona, Carlos (2024). Antidepressants for treating depression among older adults with dementia: A systematic review and meta-analysis. Psychiatry research, 340(116114), p. 116114. Elsevier 10.1016/j.psychres.2024.116114
|
Text
1-s2.0-S0165178124003998-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
BACKGROUND
Depression and dementia represent significant health challenges in older adults. Despite guidelines recommending antidepressants, their efficacy in depressed patients with dementia remains undetermined.
OBJECTIVE
This review, in following a living systematic review approach, primarily aims to determine the effect of any-type antidepressant on the level of depressive symptoms in older adults with dementia and secondly if there is an effect of any-type antidepressants on cognitive state, quality of life, and functionality in the old-age population with dementia.
METHODS
Systematic review and meta-analysis of RCTs from Medline, Embase, and Cochrane Register. Participants were ≥65 years, with both depression and any type of dementia. Certainty-of-Evidence was assessed through the Cochrane Risk-of-Bias tool and GRADE. Analysis involved standardized mean difference, with 95 % confidence-intervals (CIs).
FINDINGS
Of the 27,771 screened articles, 8 studies (617 participants), treated with SSRI, SSNRI, atypical, and tricyclic antidepressants were retained for quantitative synthesis. No evidence for an effect was found (SMD -0.10 [-0.26, 0.07]), nor when subgrouped based on depression severity or dementia level, nor for secondary outcomes.
INTERPRETATION
This review did not find evidence of a clinical effect of antidepressants for treating depression in older adults with dementia. Methodological challenges might contribute to this finding.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Geriatric Psychiatry and Psychotherapy |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Lenouvel, Eric William, Klöppel, Stefan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0165-1781 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Aug 2024 14:35 |
Last Modified: |
05 Sep 2024 00:16 |
Publisher DOI: |
10.1016/j.psychres.2024.116114 |
PubMed ID: |
39163819 |
Uncontrolled Keywords: |
Antidepressants Dementia Depression Mood disorder Neurocognitive disorder |
BORIS DOI: |
10.48350/199875 |
URI: |
https://boris.unibe.ch/id/eprint/199875 |
Actions (login required)
 |
Edit item |