[No rebound psychosis in a case of switching from clozapine to quetiapine]

Walther, Sebastian; Baciu, Dan (2006). [No rebound psychosis in a case of switching from clozapine to quetiapine]. Psychiatrische Praxis, 33(2), pp. 93-4. Stuttgart: Thieme 10.1055/s-2005-866987

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OBJECTIVE: After rapid discontinuation of clozapine treatment rebound psychosis have been reported. Preexposure of D (2) receptors to clozapine may alter their affinity to endogenous dopamine. Clozapine withdrawal may also lead dysfunctional NMDA-receptors to cause dopamine release in the striatum. METHOD: We report a case of a schizophrenic patient treated with clozapine 200 mg and aripiprazole 15 mg per day. After rapid clozapine discontinuation we added quetiapine up to 700 mg daily. RESULTS: No rebound psychosis occurred. Even ten weeks after switching to quetiapine the patient's condition remained stable in the Brief Psychiatric Rating Scale. CONCLUSIONS: The combination of aripiprazole and quetiapine seemed to control supersensitivity effects at the D (2) receptor after clozapin withdrawal in this case.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management
UniBE Contributor:	Walther, Sebastian, Baciu, Dan
ISSN:	0303-4259
ISBN:	16502388
Publisher:	Thieme
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:48
Last Modified:	05 Dec 2022 14:15
Publisher DOI:	10.1055/s-2005-866987
PubMed ID:	16502388
Web of Science ID:	000235955000008
URI:	https://boris.unibe.ch/id/eprint/20046 (FactScience: 3128)