Deposition, imaging, and clearance: what remains to be done?

Scheuch, Gerhard; Bennett, William; Borgström, Lars; Clark, Andy; Dalby, Richard; Dolovich, Myrna; Fleming, John; Gehr, Peter; Gonda, Igor; O'Callaghan, Chris; Taylor, Glyn; Newman, Steve (2010). Deposition, imaging, and clearance: what remains to be done? Journal of aerosol medicine and pulmonary drug delivery, 23 Suppl 2, S39-57. New York, N.Y.: Mary Ann Liebert 10.1089/jamp.2010.0839

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Deposition and clearance studies are used during product development and in fundamental research. These studies mostly involve radionuclide imaging, but pharmacokinetic methods are also used to assess the amount of drug absorbed through the lungs, which is closely related to lung deposition. Radionuclide imaging may be two-dimensional (gamma scintigraphy or planar imaging), or three-dimensional (single photon emission computed tomography and positron emission tomography). In October 2009, a group of scientists met at the "Thousand Years of Pharmaceutical Aerosols" conference in Reykjavik, Iceland, to discuss future research in key areas of pulmonary drug delivery. This article reports the session on "Deposition, imaging and clearance." The objective was partly to review our current understanding, but more importantly to assess "what remains to be done?" A need to standardize methodology and provide a regulatory framework by which data from radionuclide imaging methods could be compared between centers and used in the drug approval process was recognized. There is also a requirement for novel radiolabeling methods that are more representative of production processes for dry powder inhalers and pressurized metered dose inhalers. A need was identified for studies to aid our understanding of the relationship between clinical effects and regional deposition patterns of inhaled drugs. A robust methodology to assess clearance from small conducting airways should be developed, as a potential biomarker for therapies in cystic fibrosis and other diseases. The mechanisms by which inhaled nanoparticles are removed from the lungs, and the factors on which their removal depends, require further investigation. Last, and by no means least, we need a better understanding of patient-related factors, including how to reduce the variability in pulmonary drug delivery, in order to improve the precision of deposition and clearance measurements.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
UniBE Contributor:	Gehr, Peter
ISSN:	1941-2711
Publisher:	Mary Ann Liebert
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:11
Last Modified:	05 Dec 2022 14:01
Publisher DOI:	10.1089/jamp.2010.0839
PubMed ID:	21133799
Web of Science ID:	000285003700004
URI:	https://boris.unibe.ch/id/eprint/2026 (FactScience: 204177)