Enhancing BOLD response in the auditory system by neurophysiologically tuned fMRI sequence

Seifritz, Erich; Di Salle, Francesco; Esposito, Fabrizio; Herdener, Marcus; Neuhoff, John G; Scheffler, Klaus (2006). Enhancing BOLD response in the auditory system by neurophysiologically tuned fMRI sequence. NeuroImage, 29(3), pp. 1013-22. San Diego, Calif.: Elsevier 10.1016/j.neuroimage.2005.08.029

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Auditory neuroscience has not tapped fMRI's full potential because of acoustic scanner noise emitted by the gradient switches of conventional echoplanar fMRI sequences. The scanner noise is pulsed, and auditory cortex is particularly sensitive to pulsed sounds. Current fMRI approaches to avoid stimulus-noise interactions are temporally inefficient. Since the sustained BOLD response to pulsed sounds decreases with repetition rate and becomes minimal with unpulsed sounds, we developed an fMRI sequence emitting continuous rather than pulsed gradient sound by implementing a novel quasi-continuous gradient switch pattern. Compared to conventional fMRI, continuous-sound fMRI reduced auditory cortex BOLD baseline and increased BOLD amplitude with graded sound stimuli, short sound events, and sounds as complex as orchestra music with preserved temporal resolution. Response in subcortical auditory nuclei was enhanced, but not the response to light in visual cortex. Finally, tonotopic mapping using continuous-sound fMRI demonstrates that enhanced functional signal-to-noise in BOLD response translates into improved spatial separability of specific sound representations.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management 04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Psychiatric Services
UniBE Contributor:	Seifritz, Erich, Esposito, Fabio, Herdener, Marcus
ISSN:	1053-8119
ISBN:	16253522
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:49
Last Modified:	05 Dec 2022 14:15
Publisher DOI:	10.1016/j.neuroimage.2005.08.029
PubMed ID:	16253522
Web of Science ID:	000235227400034
URI:	https://boris.unibe.ch/id/eprint/20393 (FactScience: 3684)