Papassotiropoulos, Andreas; Stephan, Dietrich; Huentelmann, Matthew; Hoerndli, Frederic; Craig, David; Pearson, John; Huynh, Kim-Dung; Brunner, Fabienne; Corneveaux, Jason; Osborne, David; Wollmer, Axel; Aerni, Amanda; Coluccia, Daniel; Haenggi, Jürgen; Mondadori, Christian; Buchmann, Andreas; Reiman, Eric; Caselli, Richard; Henke, Katharina and de Quervain, Dominique (2006). Common KIBRA alleles are associated with human memory performance. Science, 314(5798), pp. 475-478. Washington, D.C.: American Association for the Advancement of Science 10.1126/science.1129837
Full text not available from this repository. (Request a copy)Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
07 Faculty of Human Sciences > Institute of Psychology > Psychological and Behavioral Health |
UniBE Contributor: |
Henke, Katharina |
ISSN: |
0036-8075 |
Publisher: |
American Association for the Advancement of Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:49 |
Last Modified: |
05 Dec 2022 14:15 |
Publisher DOI: |
10.1126/science.1129837 |
PubMed ID: |
17053149 |
Web of Science ID: |
000241382500045 |
URI: |
https://boris.unibe.ch/id/eprint/20463 (FactScience: 3765) |
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