Endothelial cell protection in xenotransplantation: looking after a key player in rejection

Banz, Yara; Rieben, Robert (2006). Endothelial cell protection in xenotransplantation: looking after a key player in rejection. Xenotransplantation, 13(1), pp. 19-30. Hoboken, N.J.: Wiley 10.1111/j.1399-3089.2005.00266.x

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The endothelium, as an organ at the interface between the intra- and extravascular space, actively participates in maintaining an anti-inflammatory and anti-coagulant environment under physiological conditions. Severe humoral as well as cellular rejection responses, which accompany cross-species transplantation of vascularized organs as well as ischemia/reperfusion injury, primarily target the endothelium and disrupt this delicate balance. Activation of pro-inflammatory and pro-coagulant pathways often lead to irreversible injury not only of the endothelial layer but also of the entire graft, with ensuing rejection. This review focuses on strategies targeted at protecting the endothelium from such damaging effects, ranging from genetic manipulation of the donor organ to soluble, as well as membrane-targeted, protective strategies.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe
UniBE Contributor:	Banz Wälti, Yara Sarah, Rieben, Robert
ISSN:	0908-665X
ISBN:	16497209
Publisher:	Wiley
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:50
Last Modified:	27 Feb 2024 14:29
Publisher DOI:	10.1111/j.1399-3089.2005.00266.x
PubMed ID:	16497209
Web of Science ID:	000235334300007
URI:	https://boris.unibe.ch/id/eprint/21015 (FactScience: 4845)