Snake venom proteins affecting platelets and their applications to anti-thrombotic research

Clemetson, Kenneth J; Lu, Qiumin; Clemetson, Jeannine M (2007). Snake venom proteins affecting platelets and their applications to anti-thrombotic research. Current pharmaceutical design, 13(28), pp. 2887-92. Hilversum: Bentham Science Publishers 10.2174/138161207782023702

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Snake venoms are very complex mixtures of biologically active proteins and peptides that may affect hemostasis in many ways, by activating or inhibiting coagulant factors or platelets, or by disrupting endothelium. They have been classified into various families, including serine proteases, metalloproteinases, C-type lectins, disintegrins and phospholipases. The various members of a particular family act selectively on different blood coagulation factors, blood cells or tissues. Venom proteins affect platelet function in particular by binding to and blocking or clustering and activating receptors or by cleaving receptors or von Willebrand factor. They may also activate protease-activated receptors or modulate ADP release or thromboxane A(2) formation. L-amino acid oxidases activate platelets by producing H(2)O(2). Many of these purified components are valuable tools in platelet research, providing new information about receptor function and signaling.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
UniBE Contributor:	Clemetson, Kenneth John
ISSN:	1381-6128
ISBN:	17979733
Publisher:	Bentham Science Publishers
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:52
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.2174/138161207782023702
PubMed ID:	17979733
Web of Science ID:	000249767200005
URI:	https://boris.unibe.ch/id/eprint/22184 (FactScience: 32220)