Baerlocher, Gabriela M; Sloand, Elaine M; Young, Neal S; Lansdorp, Peter M (2007). Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size. Experimental hematology, 35(12), pp. 1777-81. New York, N.Y.: Elsevier 10.1016/j.exphem.2007.06.010
Full text not available from this repository. (Request a copy)OBJECTIVE: To study if telomere length can be used as a surrogate marker for the mitotic history in normal and affected hematopoietic cells from patients with paroxysmal nocturnal hemoglobinuria (PNH). METHODS: The telomere length was measured by automated multicolor flow fluorescence in situ hybridization in glycosyl-phosphatidyl-inositol anchored protein (GPI)-negative and GPI-positive peripheral blood leukocytes. Eleven patients were studied, two with predominantly hemolytic PNH and nine with PNH associated with marrow failure. RESULTS: Telomere length in GPI-negative cells was significantly shorter than in GPI-positive cells of the same patient (p < 0.01, n = 11). The difference in telomere length (telomere length in GPI-positive minus telomere length in GPI-negative cells) correlated with the percentage of GPI-negative white blood cells. CONCLUSION: Our results support the hypothesis that telomere length is correlated to the replicative history of GPI-positive and GPI-negative cells and warrant further studies of telomere length in relation to disease progression in PNH.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory |
UniBE Contributor: |
Baerlocher, Gabriela M. |
ISSN: |
0301-472X |
ISBN: |
17697745 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1016/j.exphem.2007.06.010 |
PubMed ID: |
17697745 |
Web of Science ID: |
000251557600003 |
URI: |
https://boris.unibe.ch/id/eprint/22891 (FactScience: 37601) |
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