Pisoni, Giuliano; Moroni, Paolo; Turin, Lauretta; Bertoni, Giuseppe (2007). Compartmentalization of small ruminant lentivirus between blood and colostrum in infected goats. Virology, 369(1), pp. 119-30. New York, N.Y.: Academic Press 10.1016/j.virol.2007.06.021
Full text not available from this repository. (Request a copy)The compartmentalization of small ruminant lentivirus (SRLV) subtype A (Maedi-Visna virus) and B (caprine arthritis-encephalitis virus) variants was analyzed in colostrum and peripheral blood mononuclear cells of four naturally infected goats. Sequence analysis of DNA and RNA encompassing the V4-V5 env regions showed a differential distribution of SRLV variants between the two compartments. Tissue-specific compartmentalization was demonstrated by phylogenetic analysis in three of the four cases. In these animals colostrum proviral sequences were clustered relative to the blood viral sequences. In one goat, the blood and colostrum-derived provirus sequences were intermingled, suggesting trafficking of virus between the two tissues or mirroring a recent infection. Surprisingly, the pattern of free virus variants in the colostrum of all animals corresponded only partially to that of the proviral form, suggesting that free viruses might not derive from infected colostral cells. The compartmentalization of SRLV between peripheral blood and colostrum indicates that lactogenic transmission may involve specific viruses not present in the proviral populations circulating in the blood.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology |
UniBE Contributor: |
Bertoni, Giuseppe |
ISSN: |
0042-6822 |
Publisher: |
Academic Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1016/j.virol.2007.06.021 |
PubMed ID: |
17719071 |
Web of Science ID: |
000251022200011 |
URI: |
https://boris.unibe.ch/id/eprint/22935 (FactScience: 37854) |
Actions (login required)
 |
Edit item |