Chlench, Sven; Mecha Disassa, Nigussie; Hohberg, Margret; Hoffmann, Christian; Pohlkamp, Theresa; Beyer, Gabriele; Bongrazio, Mauro; Da Silva-Azevedo, Luis; Baum, Oliver; Pries, Axel Radlach; Zakrzewicz, Andreas (2007). Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress. FEBS letters, 581(4), pp. 673-80. Amsterdam: Elsevier 10.1016/j.febslet.2007.01.028d
Full text not available from this repository. (Request a copy)Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1-dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6dyn/cm(2), 24h), nuclear exclusion of Foxo-1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy |
UniBE Contributor: |
Baum, Oliver |
ISSN: |
0014-5793 |
ISBN: |
17258205 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1016/j.febslet.2007.01.028d |
PubMed ID: |
17258205 |
Web of Science ID: |
000244572300015 |
URI: |
https://boris.unibe.ch/id/eprint/23525 (FactScience: 42204) |
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