Sequential immunosuppressive therapy in progressive IgA nephropathy

Rasche, Franz Maximilian; Keller, Frieder; von Müller, Lutz; Czock, David; Lepper, Philipp M (2007). Sequential immunosuppressive therapy in progressive IgA nephropathy. Contributions to nephrology, 157, pp. 109-113. Basel: Karger 10.1159/000102313

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BACKGROUNDS: Cyclophosphamide and high-dose steroids have been used as limited induction therapy in progressive IgA nephropathy (IgAN) to reduce the loss of renal function and proteinuria. We evaluated the effect of cyclophosphamide pulses (CyP) and mycophenolic acid (MPA) as sequential therapy on renal function in patients with progressive IgAN. METHODS: Twenty patients with progressive IgAN and advanced renal failure (median GFR 22 ml/min per 1.73 m2) and further disease activity (triangle downGFR -0.8 ml/min per month) after cyclophosphamide (CyP; n = 18) or steroid pulse therapy (n = 2) were treated with mycophenolate mofetil 1 g per day for a median of 27 months. RESULTS: The monthly loss of renal function was significantly reduced in linear regression analysis from -2.4 ml/min before CyP to -0.12 ml/min with CyP/MPA (p = 0.0009). Estimated renal survival time was significantly prolonged by a median of 65 months (p = 0.0014). Proteinuria decreased significantly from 1.7 to 0.4 g/l during MPA treatment (p = 0.015). In Cox regression analysis, only proteinuria >1.0 g/l was an independent risk factor for doubling of creatinine during CyP/MPA treatment (p = 0.03). CONCLUSION: A sequential therapy with CyP/MPA may arrest or slow down the loss of renal function and reduces proteinuria even in patients who passed the so called 'point of no return' with progressive IgAN.

Item Type:	Journal Article (Original Article)
ISSN:	0302-5144
ISBN:	17495446
Publisher:	Karger
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:55
Last Modified:	08 Jun 2016 10:43
Publisher DOI:	10.1159/000102313
PubMed ID:	17495446
Web of Science ID:	000247563900017
URI:	https://boris.unibe.ch/id/eprint/23562 (FactScience: 42510)