[Endogenous hypercortisolism and immunologically-mediated disease: three cases]

Sahli, R; Diem, P; Christ, ER (2005). [Endogenous hypercortisolism and immunologically-mediated disease: three cases]. Deutsche medizinische Wochenschrift, 130(41), pp. 2316-8. Stuttgart: Thieme 10.1055/s-2005-918569

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We report three women with hypercortisolism presenting with symptoms and signs of Cushing's syndrome. In two of the patients, initial symptoms of hypercortisolism were associated with spontaneous amelioration of previously known atopic dermatitis and psoriasis, respectively. DIAGNOSTIC PROCEDURES: Diagnosis was established by demonstrating both lack of responsiveness to dexamethasone (1mg) suppression test and increased 24-hour urine cortisol secretion. One patient had a low serum ACTH level indicating Cushing's syndrome of adrenal origin. In the other two patients hypercortisolism proved to be ACTH-dependent, the source being the pituitary, as demonstrated by CRH stimulation test (elevation of ACTH and cortisol by 35 % and 20 %, respectively) and sampling of the petrosus sinus. In both patients imaging confirmed the presence of a pituitary adenoma.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
UniBE Contributor:	Sahli, Rahel Gerda, Diem, Peter, Christ, Emanuel
ISSN:	0012-0472
ISBN:	16231230
Publisher:	Thieme
Language:	German
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:56
Last Modified:	05 Dec 2022 14:17
Publisher DOI:	10.1055/s-2005-918569
PubMed ID:	16231230
Web of Science ID:	000232579200002
URI:	https://boris.unibe.ch/id/eprint/23848 (FactScience: 44833)