Krebs, J; Aebli, N; Goss, B; Sugiyama, S; Bardyn, T; Boecken, I; Leamy, P; Ferguson, SJ (2007). Cardiovascular changes after pulmonary embolism of calcium phosphate cement. Journal of biomedical materials research. Part B - applied biomaterials, 82B(2), pp. 526-532. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.b.30758
Full text not available from this repository. (Request a copy)Concerns have been raised that the use of calcium phosphate (CaP) cements for the augmentation of fractured, osteoporotic bones may aggravate cardiovascular deterioration in the event of pulmonary cement embolism by stimulating coagulation. The aim of the present study was therefore to investigate the cardiovascular changes after pulmonary embolism of CaP cement using an animal model. In 14 sheep, 2.0 mL CaP or polymethylmethacrylate cement were injected intravenously. Cardiovascular parameters and antithrombin levels were monitored until 60 min postinjection. Postmortem, lungs were subjected to CT scanning, and 3D reconstruction of the cement was performed. Intravenous injection of CaP cement resulted in a more severe increase in pulmonary arterial pressure and decrease in arterial blood pressure. Disintegration of the CaP cement seemed to be the reason for the more severe reaction. There was no evidence of thromboembolism. Disintegration of CaP cement in circulating blood does not only compromise the mechanical properties, but also represents a risk of cardiovascular complications. Reliable cohesion of CaP cements in an aqueous environment is essential for clinical applications such as osteoporotic bone augmentation.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued] |
UniBE Contributor: |
Krebs, Jörg, Ferguson, Stephen John |
ISSN: |
1552-4973 |
ISBN: |
526-532 |
Publisher: |
John Wiley & Sons |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:57 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1002/jbm.b.30758 |
PubMed ID: |
17285605 |
Web of Science ID: |
000248194100028 |
URI: |
https://boris.unibe.ch/id/eprint/24179 (FactScience: 47403) |
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