Metra, M; Ponikowski, P; Dickstein, K; McMurray, JJ; Gavazzi, A; Bergh, CH; Fraser, AG; Jaarsma, T; Pitsis, A; Mohacsi, P; Böhm, M; Anker, S; Dargie, H; Brutsaert, D; Komajda, M; Heart, Failure Association of the European Society of Cardiology (2007). Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 9(6-7), pp. 684-94. Oxford: Oxford University Press 10.1016/j.ejheart.2007.04.003
Full text not available from this repository. (Request a copy)Therapy has improved the survival of heart failure (HF) patients. However, many patients progress to advanced chronic HF (ACHF). We propose a practical clinical definition and describe the characteristics of this condition. Patients that are generally recognised as ACHF often exhibit the following characteristics: 1) severe symptoms (NYHA class III to IV); 2) episodes with clinical signs of fluid retention and/or peripheral hypoperfusion; 3) objective evidence of severe cardiac dysfunction, shown by at least one of the following: left ventricular ejection fraction<30%, pseudonormal or restrictive mitral inflow pattern at Doppler-echocardiography; high left and/or right ventricular filling pressures; elevated B-type natriuretic peptides; 4) severe impairment of functional capacity demonstrated by either inability to exercise, a 6-minute walk test distance<300 m or a peak oxygen uptake<12-14 ml/kg/min; 5) history of >1 HF hospitalisation in the past 6 months; 6) presence of all the previous features despite optimal therapy. This definition identifies a group of patients with compromised quality of life, poor prognosis, and a high risk of clinical events. These patients deserve effective therapeutic options and should be potential targets for future clinical research initiatives.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Mohacsi, Paul |
ISSN: |
1388-9842 |
ISBN: |
17481947 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1016/j.ejheart.2007.04.003 |
PubMed ID: |
17481947 |
Web of Science ID: |
000247148900020 |
URI: |
https://boris.unibe.ch/id/eprint/26130 (FactScience: 65930) |
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