Fleckenstein, M; Wolf-Schnurrbusch, U; Wolf, S; von Strachwitz, C; Holz, F G; Schmitz-Valckenberg, S (2010). [Imaging diagostics of geographic atrophy]. Ophthalmologe, 107(11), pp. 1007-15. Heidelberg: Springer-Medizin-Verlag 10.1007/s00347-010-2159-y
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The development of imaging technologies has contributed to the understanding of the genesis and pathophysiological mechanisms of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Fundus autofluorescence (FAF) imaging allows accurate discrimination of the boundaries of atrophic patches. Furthermore, predictive markers for disease progression can be identified. Non-invasive FAF imaging now represents the gold standard for evaluating progressive enlargement of atrophic areas. By means of high resolution optical coherence tomography (OCT) microstructural retinal changes in GA can be identified. Anatomical endpoints are now being used in interventional GA trials and represent meaningful outcome parameters as surrogate markers in an overall slowly progressive disease which may not affect the fovea until later stages of the disease.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Wolf-Schnurrbusch, Ute |
ISSN: |
0941-293X |
Publisher: |
Springer-Medizin-Verlag |
Language: |
German |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:12 |
Last Modified: |
05 Dec 2022 14:02 |
Publisher DOI: |
10.1007/s00347-010-2159-y |
PubMed ID: |
21088949 |
Web of Science ID: |
000284425600003 |
BORIS DOI: |
10.48350/2670 |
URI: |
https://boris.unibe.ch/id/eprint/2670 (FactScience: 205518) |
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