Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs

Jensen, Simon Storgård; Bornstein, Michael M; Dard, Michel; Bosshardt, Dieter D; Buser, Daniel (2009). Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs. Journal of biomedical materials research. Part B - applied biomaterials, 90(1), pp. 171-81. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.b.31271

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Three biphasic calcium phosphate (BCP) bone substitute materials with hydroxyapatite (HA)/tricalcium phosphate (TCP) ratios of 20/80, 60/40, and 80/20 were compared to coagulum, particulated autogenous bone, and deproteinized bovine bone mineral (DBBM) in membrane-protected bone defects. The defects were prepared in the mandibles of 24 minipigs that were divided into four groups of six with healing times of 4, 13, 26, and 52 weeks, respectively. The histologic and histomorphometric evaluation focused on differences in amount and pattern of bone formation, filler degradation, and the interface between bone and filler. Collapse of the expanded polytetrafluoroethylene barrier membrane into the coagulum defects underlined the necessity of a filler material to maintain the augmented volume. Quantitatively, BCP 20/80 showed bone formation and degradation of the filler material similar to autografts, whereas BCP 60/40 and BCP 80/20 rather equaled DBBM. Among the three BCP's, the amount of bone formation and degradation of filler material seemed to be inversely proportional to the HA/TCP ratio. The fraction of filler surface covered with bone was highest for autografts at all time points and was higher for DBBM than BCP 80/20 and 60/40 at the early healing phase. TRAP-positive multinucleated cells were identified on BCP and DBBM surfaces without showing typical signs of resorption lacunae.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
UniBE Contributor:	Jensen, Simon Storgaard, Bornstein, Michael, Bosshardt, Dieter, Buser, Daniel Albin
ISSN:	1552-4973
Publisher:	John Wiley & Sons
Language:	English
Submitter:	Eveline Carmen Schuler
Date Deposited:	04 Oct 2013 15:02
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1002/jbm.b.31271
PubMed ID:	19085941
Web of Science ID:	000267298500021
URI:	https://boris.unibe.ch/id/eprint/26823 (FactScience: 88846)