Stamer, Ulrike M; Stüber, Frank; Muders, Thomas; Musshoff, Frank (2008). Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication. Anesthesia and analgesia, 107(3), pp. 926-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1213/ane.0b013e31817b796e
Full text not available from this repository.We observed opioid-related respiratory depression in a patient receiving tramadol via patient-controlled analgesia. Predisposing factors were the patient's genetic background and renal impairment. Complete recovery occurred after naloxone administration, thus confirming opioid intoxication. Analysis of the patient's genotype revealed a CYP2D6 gene duplication resulting in ultra-rapid metabolism of tramadol to its active metabolite (+)O-desmethyltramadol. Concomitant renal impairment resulting in decreased metabolite clearance enhanced opioid toxicity. This genetic CYP2D6 variant is particularly common in specific ethnic populations and should be a future diagnostic target whenever administration of tramadol or codeine is anticipated, as both drugs are subject to a comparable CYP2D6-dependent metabolism.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy |
UniBE Contributor: |
Stüber, Frank |
ISSN: |
0003-2999 |
ISBN: |
18713907 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Jeannie Wurz |
Date Deposited: |
04 Oct 2013 15:03 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1213/ane.0b013e31817b796e |
PubMed ID: |
18713907 |
Web of Science ID: |
000258702500035 |
URI: |
https://boris.unibe.ch/id/eprint/27297 (FactScience: 105934) |
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