Völkers, Mirko; Weidenhammer, Christian; Herzog, Nicole; Qiu, Gang; Spaich, Kristin; von Wegner, Frederic; Peppel, Karsten; Müller, Oliver J; Schinkel, Stefanie; Rabinowitz, Joseph E; Hippe, Hans-Jörg; Brinks, Henriette; Katus, Hugo A; Koch, Walter J; Eckhart, Andrea D; Friedrich, Oliver; Most, Patrick (2011). The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition. Circulation research, 108(1), pp. 27-39. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.110.225201
Full text not available from this repository. (Request a copy)The G(βγ)-sequestering peptide β-adrenergic receptor kinase (βARK)ct derived from the G-protein-coupled receptor kinase (GRK)2 carboxyl terminus has emerged as a promising target for gene-based heart failure therapy. Enhanced downstream cAMP signaling has been proposed as the underlying mechanism for increased β-adrenergic receptor (βAR) responsiveness. However, molecular targets mediating improved cardiac contractile performance by βARKct and its impact on G(βγ)-mediated signaling have yet to be fully elucidated.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Heart Surgery |
UniBE Contributor: |
Most, Henriette |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0009-7330 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:13 |
Last Modified: |
27 Feb 2024 14:29 |
Publisher DOI: |
10.1161/CIRCRESAHA.110.225201 |
PubMed ID: |
21106943 |
Web of Science ID: |
000285965500008 |
URI: |
https://boris.unibe.ch/id/eprint/2747 (FactScience: 205621) |
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