Cerebral blood flow effects of acute intravenous heroin administration

Kosel, M; Noss, R.S.; Hämmig, R; Wielepp, P; Bundeli, P; Heidbreder, R; Kinser, J.A.; Brenneisen, R; Fisch, H.U.; Kayser, S; Schlaepfer, T.E. (2008). Cerebral blood flow effects of acute intravenous heroin administration. European neuropsychopharmacology, 18(4), pp. 278-285. Amsterdam: Elsevier 10.1016/j.euroneuro.2007.11.007

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We examined acute effects of intravenous diacetylmorphine (heroin) administration - which induces a characteristic biphasic response: A short rush-sensation associated with intense pleasurable feelings followed by a subjectively different period of euphoria on cerebral blood flow. This was assessed in nine male heroin dependent patients participating in a heroin maintenance program in a setting resembling everyday pattern of heroin abuse. 99mTc-HMPAO was administered 45 s (rush) and 15 min (euphoria) after administration of i.v. heroin and 45 s after administration of saline (placebo). Plasma concentration of diacetylmorphine and its metabolites were measured with high-pressure liquid chromatography (HPLC). Compared to the euphoria condition, rush was associated with blood flow increase in the left posterior cerebellar lobe, left anterior cingulate gyrus and right precuneus. Our results are in line with recent reports indicating that the cerebellum is an important component in functional brain systems subserving sensory and motor integration, learning, modulation of affect, motivation and social behaviour, which all play important roles in reinforcing properties of opioids.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > UPD Murtenstrasse 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Phytopharmakologie, Bioanalytik & Pharmakokinetik [discontinued] 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Phytopharmakologie, Bioanalytik & Pharmakokinetik [discontinued]
UniBE Contributor:	Hämmig, Robert, Brenneisen, Rudolf Max
ISSN:	0924-977X
ISBN:	278-285
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:03
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1016/j.euroneuro.2007.11.007
PubMed ID:	18207374
Web of Science ID:	000254250700006
URI:	https://boris.unibe.ch/id/eprint/27574 (FactScience: 108903)