Pelivani, Nedzmidin; Hassan, Akmal S; Braathen, Lasse R; Hunger, Robert E; Yawalkar, Nikhil (2008). Alopecia areata universalis elicited during treatment with adalimumab. Dermatology, 216(4), pp. 320-3. Basel: Karger 10.1159/000113945
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Adalimumab is a fully humanized recombinant anti-tumour-necrosis-factor (TNF-alpha) monoclonal antibody which has been approved for rheumatoid arthritis, active ankylosing spondylitis, psoriatic arthritis and Crohn's disease. We report a case of alopecia areata (AA) universalis occurring 6 months after administration of adalimumab monotherapy in a patient with a long-standing history of psoriatic arthritis and psoriasis. The diagnosis was confirmed by a scalp biopsy which showed a peribulbar infiltrate of both CD4+ and CD8+ T cells, CD1a+ dendritic cells as well as CD68+ and CD163+ macrophages. In addition, immunofluorescence staining for TNF-alpha was found in the mononuclear cell infiltrate. This case suggests a complex role of TNF-alpha in the induction of AA.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Hunger, Robert, Yawalkar, Nikhil |
ISSN: |
1018-8665 |
ISBN: |
18230980 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:04 |
Last Modified: |
21 Jun 2023 11:53 |
Publisher DOI: |
10.1159/000113945 |
PubMed ID: |
18230980 |
Web of Science ID: |
000253912000007 |
BORIS DOI: |
10.48350/27678 |
URI: |
https://boris.unibe.ch/id/eprint/27678 (FactScience: 109911) |
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