Henschkowski, Jana; Stuck, Andreas E; Frey, Brigitte M; Gillmann, Gerhard; Dick, Bernhard; Frey, Felix J; Mohaupt, Markus G (2008). Age-dependent decrease in 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in hypertensive patients. American journal of hypertension, 21(6), pp. 644-9. Oxford: Oxford University Press 10.1038/ajh.2008.152
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BACKGROUND: The prevalence of arterial hypertension lacking a defined underlying cause increases with age. Age-related arterial hypertension is insufficiently understood, yet known characteristics suggest an aldosterone-independent activation of the mineralocorticoid receptor. Therefore, we hypothesized that 11beta-HSD2 activity is age-dependently impaired, resulting in a compromised intracellular inactivation of cortisol (F) with F-mediated mineralocorticoid hypertension. METHODS: Steroid hormone metabolites in 24-h urine samples of 165 consecutive hypertensive patients were analyzed for F and cortisone (E), and their TH-metabolites tetrahydro-F (THF), 5alphaTHF, TH-deoxycortisol (THS), and THE by gas chromatography-mass spectroscopy. Apparent 11beta-HSD2 and 11beta-hydroxylase activity and excretion of F metabolites were assessed. RESULTS: In 72 female and 93 male patients aged 18-84 years, age correlated positively with the ratios of (THF + 5alphaTHF)/THE (P = 0.065) and F/E (P < 0.002) suggesting an age-dependent reduction in the apparent 11beta-HSD2 activity, which persisted (F/E; P = 0.020) after excluding impaired renal function. Excretion of F metabolites remained age-independent most likely as a consequence of an age-dependent diminished apparent 11beta-hydroxylase activity (P = 0.038). CONCLUSION: Reduced 11beta-HSD2 activity emerges as a previously unrecognized risk factor contributing to the rising prevalence of arterial hypertension in elderly. This opens new perspectives for targeted treatment of age-related hypertension.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Geriatric Clinic 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Stuck, Andreas, Frey, Brigitte, Gillmann, Gerhard, Frey, Felix (B), Mohaupt, Markus |
ISSN: |
0895-7061 |
ISBN: |
18443572 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Markus Georg Mohaupt |
Date Deposited: |
04 Oct 2013 15:04 |
Last Modified: |
29 Mar 2023 23:33 |
Publisher DOI: |
10.1038/ajh.2008.152 |
PubMed ID: |
18443572 |
Web of Science ID: |
000255841800012 |
BORIS DOI: |
10.7892/boris.27794 |
URI: |
https://boris.unibe.ch/id/eprint/27794 (FactScience: 111528) |
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