Strategies to advance translational research into brain barriers

Neuwelt, Edward; Abbott, N Joan; Abrey, Lauren; Banks, William A; Blakley, Brian; Davis, Thomas; Engelhardt, Britta; Grammas, Paula; Nedergaard, Maiken; Nutt, John; Pardridge, William; Rosenberg, Gary A; Smith, Quentin; Drewes, Lester R (2008). Strategies to advance translational research into brain barriers. Lancet neurology, 7(1), pp. 84-96. Oxford: Elsevier 10.1016/S1474-4422(07)70326-5

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There is a paucity of therapies for most neurological disorders--from rare lysosomal storage diseases to major public health concerns such as stroke and Alzheimer's disease. Advances in the targeting of drugs to the CNS are essential for the future success of neurotherapeutics; however, the delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by the blood-brain barrier, the blood-CSF barrier, or other specialised CNS barriers. These brain barriers are now recognised as a major obstacle to the treatment of most brain disorders. The challenge to deliver therapies to the CNS is formidable, and the solution will require concerted international efforts among academia, government, and industry. At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
UniBE Contributor:	Engelhardt, Britta
ISSN:	1474-4422
ISBN:	18093565
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:05
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.1016/S1474-4422(07)70326-5
PubMed ID:	18093565
Web of Science ID:	000252063300029
URI:	https://boris.unibe.ch/id/eprint/28199 (FactScience: 118502)