Mullis, (2010). Biological determinants of responsiveness to growth hormone: pharmacogenomics and personalized medicine. Endocrine development, 18, pp. 67-82. Basel: Karger
Full text not available from this repository.It is becoming most clear that many genes are involved in controlling the regulation of growth. Ultimately however, at the level of growth hormone (GH), the relevant question may be not whether a patient is GH-deficient, but whether he is GH-responsive. As these disturbances can be divided into two gross categories, namely alterations causing subnormal GH secretion and/or those presenting with subnormal GH sensitivity/responsiveness, the main aim of this review is to focus on genes involved in growth regulation leading to short stature caused by an alteration of GH insensitivity/GH responsiveness; in other words, clinical circumstances where individually adapted GH replacement therapy may help to increase height velocity and eventually final height.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Mullis, Primus-Eugen |
ISSN: |
1421-7082 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:13 |
Last Modified: |
05 Dec 2022 14:02 |
PubMed ID: |
20523018 |
URI: |
https://boris.unibe.ch/id/eprint/2864 (FactScience: 205797) |
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