Hilti, Caroline Claudia; Hilti, Leonie Maria; Heinemann, Dörthe; Robbins, Trevor; Seifritz, Erich; Cattapan-Ludewig, Katja (2010). Impaired performance on the rapid visual information processing task (RVIP) could be an endophenotype of schizophrenia. Psychiatry research, 177(1-2), pp. 60-4. Amsterdam: Elsevier 10.1016/j.psychres.2009.12.012
Full text not available from this repository.The aim of the present study was to investigate whether healthy first-degree relatives of schizophrenia patients show reduced sensitivity performance, higher intra-individual variability (IIV) in reaction time (RT), and a steeper decline in sensitivity over time in a sustained attention task. Healthy first-degree relatives of schizophrenia patients (n=23) and healthy control subjects (n=46) without a family history of schizophrenia performed a demanding version of the Rapid Visual Information Processing task (RVIP). RTs, hits, false alarms, and the sensitivity index A' were assessed. The relatives were significantly less sensitive, tended to have higher IIV in RT, but sustained the impaired level of sensitivity over time. Impaired performance on the RVIP is a possible endophenotype for schizophrenia. Higher IIV in RT, apparently caused by impaired context representations, might result in fluctuations in control and lead to more frequent attentional lapses.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology [discontinued] 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management |
UniBE Contributor: |
Hilti, Caroline Claudia, Heinemann, Dörthe, Seifritz, Erich, Cattapan-Ludewig, Katja |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0165-1781 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:13 |
Last Modified: |
02 Mar 2023 23:20 |
Publisher DOI: |
10.1016/j.psychres.2009.12.012 |
PubMed ID: |
20110130 |
Web of Science ID: |
000278278800011 |
URI: |
https://boris.unibe.ch/id/eprint/2991 (FactScience: 206085) |
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