Emons, Günter; Kaufmann, Manfred; Gorchev, Grigor; Tsekova, Valentina; Gründker, Carsten; Günthert, Andreas R; Hanker, Lars C; Velikova, Maya; Sindermann, Herbert; Engel, Jürgen; Schally, Andrew V (2010). Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors. Gynecologic oncology, 119(3), pp. 457-61. Orlando, Fla.: Elsevier 10.1016/j.ygyno.2010.08.003
Full text not available from this repository.Receptors for luteinizing hormone-releasing hormone (LHRH) can be utilized for targeted chemotherapy of cytotoxic LHRH analogs. The compound AEZS-108 (previously AN-152) consists of [D-Lys?]LHRH linked to doxorubicin. The objectives of this first study in humans with AESZ-108 were to determine the maximum tolerated dose and to characterize the dose-limiting toxicity, pharmacokinetics, preliminary efficacy, and hormonal effects.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Günthert, Andreas Reinhold |
ISSN: |
0090-8258 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:13 |
Last Modified: |
05 Dec 2022 14:02 |
Publisher DOI: |
10.1016/j.ygyno.2010.08.003 |
PubMed ID: |
20828803 |
Web of Science ID: |
000284556800011 |
URI: |
https://boris.unibe.ch/id/eprint/3143 (FactScience: 206614) |
Actions (login required)
 |
Edit item |