Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature

Kraoua, Ichraf; Stirnemann, Jérôme; Ribeiro, Maria João; Rouaud, Tiphaine; Verin, Marc; Annic, Agnès; Rose, Christian; Defebvre, Luc; Réménieras, Liliane; Schüpbach, Michaël; Belmatoug, Nadia; Vidailhet, Marie; Sedel, Frédéric (2009). Parkinsonism in Gaucher's disease type 1: ten new cases and a review of the literature. Movement disorders, 24(10), pp. 1524-30. Hoboken, N.J.: Wiley-Blackwell 10.1002/mds.22593

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Parkinsonism has been described in patients with Gaucher's disease (GD). We reviewed the 10 cases of patients with both parkinsonism and GD recorded in the French national GD registry, as well as 49 previously published cases. Relative to the general population, parkinsonism in GD patients (1) was more frequent, (2) occurred at an earlier age, (3) responded less well to levodopa, and (4) was more frequently associated with signs of cortical dysfunction. Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) were ineffective on GD-associated parkinsonism, suggesting that parkinsonism itself is not an indication for ERT or SRT in this setting.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
UniBE Contributor:	Schüpbach, Michael
ISSN:	0885-3185
Publisher:	Wiley-Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:14
Last Modified:	05 Dec 2022 14:22
Publisher DOI:	10.1002/mds.22593
PubMed ID:	19513999
Web of Science ID:	000268613600015
URI:	https://boris.unibe.ch/id/eprint/32634 (FactScience: 197895)