Hysteroscopic findings in women with two and with more than two first-trimester miscarriages are not significantly different

Bohlmann, Michael K; von Wolff, Michael; Luedders, Doerte W; Beuter-Winkler, Petra; Diedrich, Klaus; Hornemann, Amadeus; Strowitzki, Thomas (2010). Hysteroscopic findings in women with two and with more than two first-trimester miscarriages are not significantly different. Reproductive biomedicine online, 21(2), pp. 230-6. Oxford: Elsevier 10.1016/j.rbmo.2010.04.016

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The purpose of this study was to analyse hysteroscopic results in patients with recurrent miscarriages and to compare the frequency of uterine anomalies in women with a history of exactly two and with more than two consecutive miscarriages. A retrospective analysis of 206 patients undergoing hysteroscopy for repeated early pregnancy losses was performed at two university centres. Late miscarriages were excluded, terminations of pregnancy were not counted. Eighty-seven patients had suffered from exactly two early miscarriages and 119 from more than two. Both groups were comparable with respect to age at admission (32.95+/-4.46 versus 34.06+/-5.02 years) and at first miscarriage (30.43+/-4.24 versus 29.08+/-5.38 years). The prevalence of acquired (adhesions, polyps, fibroids) and congenital uterine anomalies (septate or bicornuate uterus, etc.) did not differ significantly (acquired: 28.7 versus 27.7%; congenital: 9.2 versus 16.8%). The rates of uterine anomalies did not differ significantly overall (36.8 versus 42.9%). In conclusion, uterine anomalies are frequently found in patients with two and with more than two early miscarriages. Due to the high rate of anomalies, their risk for adverse pregnancy outcome and a possible therapeutic approach, hysteroscopy might be a diagnostic option even after two early miscarriages.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
UniBE Contributor:	von Wolff, Michael
ISSN:	1472-6483
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:14
Last Modified:	05 Dec 2022 14:02
Publisher DOI:	10.1016/j.rbmo.2010.04.016
PubMed ID:	20541468
Web of Science ID:	000281172300011
URI:	https://boris.unibe.ch/id/eprint/3278 (FactScience: 206917)