Prevention of stroke in patients with patent foramen ovale

Mattle, H P; Meier, B; Nedeltchev, K (2010). Prevention of stroke in patients with patent foramen ovale. International journal of stroke, 5(2), pp. 92-102. Oxford: Blackwell Publishing

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Patent foramen ovale is found in 24% of healthy adults and 38% of patients with cryptogenic stroke. This ratio and case reports indicate that patent foramen ovale and stroke are associated, probably because of paradoxical embolism. In healthy people with patent foramen ovale, embolic events are not more frequent than in controls, and therefore no primary prevention is needed. However, once ischaemic events occur, the risk of recurrence is substantial and prevention becomes an issue. Acetylsalicylic acid and warfarin reduce this risk to the same level as in patients without patent foramen ovale. Patent foramen ovale with a coinciding atrial septal aneurysm, spontaneous or large right-to-left shunt, or multiple ischaemic events potentiates the risk of recurrence. Transcatheter device closure has therefore become an intriguing addition to medical treatment, but its therapeutic value still needs to be confirmed by randomised-controlled trials.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Mattle, Heinrich, Meier, Bernhard, Nedeltchev, Krassen
ISSN:	1747-4930
Publisher:	Blackwell Publishing
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:08
Last Modified:	05 Dec 2022 14:00
PubMed ID:	20446943
Web of Science ID:	000275336500008
URI:	https://boris.unibe.ch/id/eprint/374 (FactScience: 197875)