Quantitative mRNA analysis of muscarinic acetylcholine receptors in the intestine of dairy cows with spontaneous caecal dilatation-dislocation

Ontsouka, Edgar; Steiner, Adrian; Bruckmaier, Rupert; Blum, J.W.; Meylan, Mireille (2009). Quantitative mRNA analysis of muscarinic acetylcholine receptors in the intestine of dairy cows with spontaneous caecal dilatation-dislocation. Veterinary journal, 180(2), pp. 259-61. Amsterdam: Elsevier 10.1016/j.tvjl.2007.11.021

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Muscarinic receptors mediate acetylcholine-induced muscular contractions. In this study, mRNA levels of muscarinic receptor subtypes 2 and 3 (M(2) and M(3)) in the ileum, caecum, proximal loop of the ascending colon (PLAC) and external loop of the spiral colon (ELSC) were determined by quantitative polymerase chain reaction in seven cows with caecal dilatation-dislocation (CDD) and seven healthy control cows. Levels of M(2) were significantly lower in the caecum, PLAC and ELSC and levels of M(3) were significantly lower in the ileum, caecum, PLAC and ELSC of cows with CDD compared to healthy cows (P<0.05). Down-regulation of M(3) may play a role in the pathogenesis of CDD.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology
UniBE Contributor:	Ontsouka, Corneille Edgar, Steiner, Adrian, Bruckmaier, Rupert, Meylan, Mireille
Subjects:	600 Technology > 630 Agriculture
ISSN:	1090-0233
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:25
Last Modified:	02 Mar 2023 23:23
Publisher DOI:	10.1016/j.tvjl.2007.11.021
Web of Science ID:	000264897500018
URI:	https://boris.unibe.ch/id/eprint/38384 (FactScience: 221261)