An unmatched case controlled study of clinicopathologic abnormalities in dogs with Bartonella infection

Pérez Vera, Cristina; Diniz, Pedro Paulo V.P.; Pultorak, Elizabeth L.; Maggi, Ricardo G.; Breitschwerdt, Edward B. (2013). An unmatched case controlled study of clinicopathologic abnormalities in dogs with Bartonella infection. Comparative immunology, microbiology and infectious diseases, 36(5), pp. 481-487. Elsevier 10.1016/j.cimid.2013.04.001

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We compared clinicopathologic findings in dogs with Bartonella infection to Bartonella spp. negative dogs suspected of a vector-borne disease. Cases (n=47) and controls (n=93) were selected on the basis of positive or negative enrichment culture PCR results, respectively. Signalment, clinicopathologic findings and treatments were extracted from medical records. DNA sequencing identified Bartonella henselae (n=28, 59.6%), Bartonella vinsonii subsp. berkhoffii (n=20, 42.6%), Bartonella koehlerae (n=3, 6.4%), Bartonella volans-like (n=3, 6.4%) and Bartonella bovis (n=1, 2.1%). There were no significant differences in age, breed, size, sex or neuter status between cases and controls. Dogs infected with Bartonella sp. often had a history of weight loss [OR=2.82; 95% CI: 1.08-7.56] and were hypoglobulinemic [OR=4.26; 95% CI: 1.31-14.41]. With the exception of weight loss and hypoglobulinemia, clinicopathologic abnormalities in Bartonella-infected dogs in this study were similar to dogs suspected of other vector-borne infections.

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