Van Belle, E; Nikol, S; Norgren, L; Baumgartner, I; Driver, V; Hiatt, W R; Belch, J (2011). Insights on the role of diabetes and geographic variation in patients with critical limb ischaemia. European journal of vascular and endovascular surgery EJVES, 42(3), pp. 365-73. London: Elsevier 10.1016/j.ejvs.2011.04.030
Full text not available from this repository. (Request a copy)Patients with critical limb ischaemia (CLI) unsuitable for revascularisation have a high rate of amputation and mortality (30% and 25% at 1 year, respectively). Localised gene therapy using plasmid DNA encoding acidic fibroblast growth factor (NV1FGF, riferminogene pecaplasmid) has showed an increased amputation-free survival in a phase II trial. This article provides the rationale, design and baseline characteristics of CLI patients enrolled in the pivotal phase III trial (EFC6145/TAMARIS).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology |
UniBE Contributor: |
Baumgartner, Iris |
ISSN: |
1078-5884 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:15 |
Last Modified: |
05 Dec 2022 14:03 |
Publisher DOI: |
10.1016/j.ejvs.2011.04.030 |
PubMed ID: |
21696982 |
Web of Science ID: |
000295061800015 |
URI: |
https://boris.unibe.ch/id/eprint/4286 (FactScience: 208446) |
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