Prognostic relevance of coronary collateral function: confounded or causal relationship?

Seiler, Christian; Engler, Rebecca; Berner, Lea; Stoller, Michael; Meier, Pascal; Steck, Hélène; Traupe, Tobias (2013). Prognostic relevance of coronary collateral function: confounded or causal relationship? Heart, 99(19), pp. 1408-14. BMJ Publishing Group 10.1136/heartjnl-2013-304369

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OBJECTIVE

To expand the limited information on the prognostic impact of quantitatively obtained collateral function in patients with coronary artery disease (CAD) and to estimate causality of such a relation.

DESIGN

Prospective cohort study with long-term observation of clinical outcome.

SETTING

University Hospital.

PATIENTS

One thousand one hundred and eighty-one patients with chronic stable CAD undergoing 1771 quantitative, coronary pressure-derived collateral flow index measurements, as obtained during a 1-min coronary balloon occlusion (CFI is the ratio between mean distal coronary occlusive pressure and mean aortic pressure both subtracted by central venous pressure). Subgroup of 152 patients included in randomised trials on the longitudinal effect of different arteriogenic protocols on CFI.

INTERVENTIONS

Collection of long-term follow-up information on clinical outcome.

MAIN OUTCOME MEASURES

All-cause mortality and major adverse cardiac events.

RESULTS

Cumulative 15-year survival rate was 48% in patients with CFI<0.25 and 65% in the group with CFI≥0.25 (p=0.0057). Cumulative 10-year survival rate was 75% in patients without arteriogenic therapy and 88% (p=0.0482) in the group with arteriogenic therapy and showing a significant increase in CFI at follow-up. By proportional hazard analysis, the following variables predicted increased all-cause mortality: age, low CFI, left ventricular end-diastolic pressure and number of vessels with CAD.

CONCLUSIONS

A well-functioning coronary collateral circulation independently predicts lowered mortality in patients with chronic CAD. This relation appears to be causal, because augmented collateral function by arteriogenic therapy is associated with prolonged survival.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Seiler, Christian, Stoller, Michael, Steck, Hélène, Traupe, Tobias
Subjects:	600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology
ISSN:	1355-6037
Publisher:	BMJ Publishing Group
Language:	English
Submitter:	PD Dr. Tobias Traupe
Date Deposited:	24 Mar 2014 08:59
Last Modified:	05 Dec 2022 14:29
Publisher DOI:	10.1136/heartjnl-2013-304369
PubMed ID:	23886607
URI:	https://boris.unibe.ch/id/eprint/43354