The Fascinating Coat Surrounding Mycobacteria

Daffé, Mamadou; Zuber, Benoît (2014). The Fascinating Coat Surrounding Mycobacteria. In: Remaut, Han; Fronzes, Remy (eds.) Bacterial Membranes: Structural and Molecular Biology (pp. 179-192). Norfolk: Caister Academic Press

Full text not available from this repository.

The mycobacterial cell envelope is fascinating in several ways. First, its composition is unique by the exceptional lipid content, which consists of very long-chain (up to C90) fatty acids, the so-called mycolic acids, and a variety of exotic compounds. Second, these lipids are atypically organized into a Gram-negative-like outer membrane (mycomembrane) in these Gram-positive bacteria, as recently revealed by CEMOVIS, and this mycomembrane also contains pore-forming proteins. Third, the mycolic acids esterified a holistic heteropolysaccharide (arabinogalacan), which in turn is linked to the peptidoglycan to form the cell wall skeleton (CWS). In slow-growing pathogenic mycobacterial species, this giant structure is surrounded by a capsular layer composed mainly of polysaccharides, primarily a glycogen-like glucan. The CWS is separated from the plasma membrane by a periplasmic space. A challenging research avenue for the next decade comprises the identification of the components of the uptake and secretion machineries and the isolation and biochemical characterization of the mycomembrane.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Zuber, Benoît

Subjects:

600 Technology > 610 Medicine & health

ISBN:

9781908230270

Publisher:

Caister Academic Press

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

09 Oct 2014 08:41

Last Modified:

05 Dec 2022 14:31

URI:

https://boris.unibe.ch/id/eprint/47225

Actions (login required)

Edit item Edit item
Provide Feedback