Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease

Muller, Olivier; Ntalianis, Argyrios; Wijns, William; Delrue, Leen; Dierickx, Karen; Auer, Reto; Rodondi, Nicolas; Mangiacapra, Fabio; Trana, Catalina; Hamilos, Michalis; Valentin, Emmanuel; De Bruyne, Bernard; Barbato, Emanuele; Bartunek, Jozef (2013). Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease. Journal of cardiovascular translational research JCTR, 6(4), pp. 536-544. Springer 10.1007/s12265-013-9468-x

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Biomarkers of blood lipid modification and oxidative stress have been associated with increased cardiovascular morbidity. We sought to determine whether these biomarkers were related to functional indices of stenosis severity among patients with stable coronary artery disease. We studied 197 consecutive patients with stable coronary artery disease due to single vessel disease. Fractional flow reserve (FFR) ≤ 0.80 was assessed as index of a functionally significant lesion. Serum levels of secretory phospholipase A2 (sPLA2) activity, secretory phospholipase A2 type IIA (sPLA2-IIA), myeloperoxydase (MPO), lipoprotein-associated phospholipase A2 (Lp-PLA2), and oxidized low-density lipoprotein (OxLDL) were assessed using commercially available assays. Patients with FFR > 0.8 had higher sPLA2 activity, sPLA2 IIA, and OxLDL levels than patients with FFR ≤ 0.8 (21.25 [16.03-27.28] vs 25.85 [20.58-34.63] U/mL, p < 0.001, 2.0 [1.5-3.4] vs 2.6 [2.0-3.4] ng/mL, p < 0.01; and 53.0 [36.0-71.0] vs 64.5 [50-89.25], p < 0.001 respectively). Patients with FFR > 0.80 had similar Lp-PLA2 and MPO levels versus those with FFR ≤ 0.8. sPLA2 activity, sPLA2 IIA significantly increased area under the curve over baseline characteristics to predict FFR ≤ 0.8 (0.67 to 0.77 (95 % confidence interval [CI]: 0.69-0.85) p < 0.01 and 0.67 to 0.77 (95 % CI: 0.69-0.84) p < 0.01, respectively). Serum sPLA2 activity as well as sPLA2-IIA level is related to functional characteristics of coronary stenoses in patients with stable coronary artery disease.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
UniBE Contributor:	Rodondi, Nicolas
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1937-5387
Publisher:	Springer
Language:	English
Submitter:	Patricia Rajaonina
Date Deposited:	01 Apr 2014 11:36
Last Modified:	05 Dec 2022 14:32
Publisher DOI:	10.1007/s12265-013-9468-x
PubMed ID:	23670230
URI:	https://boris.unibe.ch/id/eprint/49598