True four-dimensional analysis of thoracic aortic displacement and distension using model-based segmentation of computed tomography angiography.

Weber, Tim F; Müller, Tobias; Biesdorf, Andreas; Wörz, Stefan; Rengier, Fabian; Heye, Tobias; Holland-Letz, Tim; Rohr, Karl; Kauczor, Hans-Ulrich; von Tengg-Kobligk, Hendrik (2014). True four-dimensional analysis of thoracic aortic displacement and distension using model-based segmentation of computed tomography angiography. The international journal of cardiovascular imaging, 30(1), pp. 185-194. Springer 10.1007/s10554-013-0307-6

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Previous analyses of aortic displacement and distension using computed tomography angiography (CTA) were performed on double-oblique multi-planar reformations and did not consider through-plane motion. The aim of this study was to overcome this limitation by using a novel computational approach for the assessment of thoracic aortic displacement and distension in their true four-dimensional extent. Vessel segmentation with landmark tracking was executed on CTA of 24 patients without evidence of aortic disease. Distension magnitudes and maximum displacement vectors (MDV) including their direction were analyzed at 5 aortic locations: left coronary artery (COR), mid-ascending aorta (ASC), brachiocephalic trunk (BCT), left subclavian artery (LSA), descending aorta (DES). Distension was highest for COR (2.3 ± 1.2 mm) and BCT (1.7 ± 1.1 mm) compared with ASC, LSA, and DES (p < 0.005). MDV decreased from COR to LSA (p < 0.005) and was highest for COR (6.2 ± 2.0 mm) and ASC (3.8 ± 1.9 mm). Displacement was directed towards left and anterior at COR and ASC. Craniocaudal displacement at COR and ASC was 1.3 ± 0.8 and 0.3 ± 0.3 mm. At BCT, LSA, and DES no predominant displacement direction was observable. Vessel displacement and wall distension are highest in the ascending aorta, and ascending aortic displacement is primarily directed towards left and anterior. Craniocaudal displacement remains low even close to the left cardiac ventricle.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
UniBE Contributor:	von Tengg-Kobligk, Hendrik
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1875-8312
Publisher:	Springer
Language:	English
Submitter:	Aisha Stefania Mzinga
Date Deposited:	09 Oct 2014 16:18
Last Modified:	05 Dec 2022 14:34
Publisher DOI:	10.1007/s10554-013-0307-6
PubMed ID:	24135852
URI:	https://boris.unibe.ch/id/eprint/52300